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Motor symptoms including muscle weakness, muscle wasting or distal muscle cramps, loss of tendon reflexes, gait and balance disturbances, and impaired motor movement often develop in severe cases (Zajczkowska et al., 2019)

JAMA: The Journal Of The American Medical Association 2023, 330: 821-831

CPZ intoxication mimics several degenerative events in the brain, inducing demyelination, loss of OLs, axonal and synaptic dysfunction, glial cell activation, and oxidative stress, recapitulating cellular and molecular degenerative features of demyelinating diseases 31,32,33,34

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Like normal HSCs, LSCs reside in the BM niche of AML patients (23) which supports their survival and protects them against chemotherapeutic drug treatment (2426)

Natural helpers like citrulline, niacin, vitamin D, zinc, and magnesium can support blood flow, but they work best with a healthy lifestyle