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Hypoxia induces the mitochondrial NDUFA4L2 (NADH dehydrogenase [ubiquinone] 1 alpha subcomplex, 4-like 2) gene in a HIF-1-dependent manner to decrease complex I activity and respiration through unknown mechanisms 98

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Akhmetshina A, Palumbo K, Dees C, Bergmann C, Venalis P, Zerr P, et al

While this finding was discussed in the context of peripheral clock function, we speculate that it may also suggest that the central pacemakers role is less dominant than traditionally assumed, and that peripheral clocks can, under certain conditions, exert substantial autonomous control over specific physiological functions or even over organismal homeostasis

In the expression of genome-encoded proteins, integration of genome offers lower copy number of gene