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Chemotherapy-induced peripheral neuropathy prevention and treatment: therapy candidates for OIPN The National Cancer Institutes Symptom Management and Health-Related Quality of Life Steering Committee has announced that CIPN is a priority area in translational research in cancer care [137]

Importantly, such platforms hold potential for self-adjusting performance in response to interpatient variability in SC tissue characteristics, thereby enhancing safety and adherence across diverse patient populations [103]

In these instances, the lowest observed adverse effect level (LOAEL) was the lowest dose at which the effect was seen

doi: 10.1097/00054725-200201000-00005

Recently the lipid peroxidation product 4-HNE was shown to directly adduct GCLC Cys553 (and GCLM Cys35) in vitro [132]