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Alpha Lipoic Acid May Mitigate Oxidative Stress in Nerves Oxidative stress can damage tissues and nerves

A study on spinal cord injury demonstrated that the introduction of lactate significantly augments lactylation levels in microglia, effectively inhibiting the expression of pro-inflammatory mediators such as IL-1, iNOS, and TNF- [57]

Nature 477, 211215

GSH is a necessary cofactor for GPX4 (glutathione peroxidase 4), a selenoprotein that contains a catalytic site for selenocysteine to exert its antioxidant function in eliminating lipid peroxides (Figure 2A)

Each peptide acts on its own receptors independently after injection

WPF, DPM and PPC samples and 3 mM of 1,10-phenanthroline were separately dissolved in 0.1 M sodium phosphate buffer (pH 7.4)