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The primary outcome of this trial was the percentage of patients with incident LIDs by month 18 and showed a statistically significant difference in favor of amantadine (11% vs 22% on placebo

To do so, measured M concentration of target metabolite in the erythrocyte fraction was divided on concentration factor after gradient

In fact, the loss of FH has been previously associated with the increased production of reactive oxygen species (ROS) 9 , and the accumulation of fumarate in FH-deficient cancer cell lines leads to the formation of an adduct between fumarate and glutathione (GSH), which depletes intracellular NADPH and enhances oxidative stress 10

Neuropsychopharmacology 34 , 13631380 (2009)

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