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It has been assigned Generally Recognized As Safe (GRAS) status by the FDA for food, beverage, and dietary supplement applications

High flow POTS may be due to vasodilation instead of vasoconstriction

Studies investigating the effect of vitamin B12 (cobalamin) and folic acid supplementation in boosting energy and fighting fatigue are promising

Discontinue use and consult a doctor if any adverse reactions occur

doi:10.1124/jpet.107.121715