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Contemporary lifestyles, often marked by factors such as nighttime exposure to artificial light, rotating night shift schedules, social jet lag, irregular sleep-wake cycles, and inconsistent eating patterns, frequently disrupt the natural rhythm of the circadian clock, leading to circadian misalignment. This phenomenon is believed to contribute to global health challenges, including obesity, non-alcoholic fatty liver disease (NAFLD), and non-alcoholic steatohepatitis (NASH) [33]

The pharmaceutical formulation disclosed herein may comprise a cyclodextrin of the hydroxypropyl-substituted alpha type, comprising six ring-arranged glucose units

MDPI AG 10 , 171 (2020)

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doi: 10.1042/CS20171330 58 WirthKScheibenbogenC

Lebedeva et al., 2014