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Agencies such as the FDA and EMA now apply nanotechnology guidance that emphasize detailed physicochemical characterization, stability profiling, immunotoxicity assessment, and biodistribution studies, particularly for long-acting injectable systems like cabotegravir and rilpivirine [144]

The immunoglobulin fold family: sequence analysis and 3D structure comparisons

Neurological research indicates neuroprotective properties, with studies demonstrating benefits in traumatic brain injury models, improved recovery from peripheral nerve injuries, and protective effects against neurotoxins

Validity and reliability of the patient-reported outcomes version of the common terminology criteria for adverse events (PRO-CTCAE)

Maldonado M, et al

for each additional point in the NRS, QoL changed by -3.33 units (95%CI -4.46, -2.20)