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HMGA1 similarly modulates autophagy in a tissue-specific manner, suppressing ULK1 transcription and activating mTOR in cancer and cardiomyopathy while promoting miRNA-mediated autophagy activation in neurodegenerative models (Fig

As oligodendrocytes are the main sites of iron storage in the brain 24 , the stimulation of FPN1-mediated iron export via decreased hepcidin is expected to increase free extracellular iron, which may, in turn, result in oxidative stress in the SN in PD patients

doi: 10.1016/j.cell.2016.05.039 185 MatheoudDCannonTVoisinAPenttinenA-MRametLFahmyAMet al

IGF-1 LR3 (Insulin-Like Growth Factor-1 Long R3) is a modified analog of naturally occurring IGF-1

Ng Y, Wolfe A, Novaira HJ, et al

As a consequence of ATP reduction, damaged mitochondria are repaired through the fusion with healthy mitochondria, or mitochondrial fission enables the segregation of damaged mitochondria and subsequent elimination via mitophagy (Liu et al., 2018)