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Finkelstein J, Martin J: Methionine metabolism in mammals: distribution of homocysteine between competing pathways

Decreased transcription of the GSH-synthesising enzymes (GCLC and GSS) due to the inhibition of NRF2 was responsible for low GSH levels in resistant cells that was directly linked to the T790M mutation

Currently, 264 ferroptosis-driving targets and 238 ferroptosis-inhibition targets have been identified

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Altogether, these data point to non-specific iron binding via electrostatic interactions, which is not consistent with the proposed function of frataxin as an iron chaperone