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Moreover, following signaling pathways like IL-6, TNF-, Notch pathway, Wnt/-catenin, HGF, TGF- pathway and PI3K/AKT/mTOR pathway are also involved (191)

Frozen products can lose folate during storage due to oxidation, in contrast to canned products, which can lose more during the initial thermal treatment, but then are relatively stable because of the lack of oxygen 293

Kart T, Christrup L, Rasmussen M

Dysregulation of DNA methylation patterning can occur by several mechanisms including defective or decreased activity of DNMT or TET DNA demethylases that leads to hypomethylation and/or hypermethylation