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Pediatric AIH is typically characterized by hypergammaglobulinemia (raised IgG levels), indicating ongoing histological activity, although up to 15% of children with AIH-1 and 25% of AIH-2 may have normal IgG levels, particularly in acute fulminant presentations [9, 29, 43]

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10.3390/IJMS16035666 [DOI] [PMC free article] [PubMed] [Google Scholar] [63].Huang S., Que H., Wang M., Wei X

J Immunol 175(12):79657972 Halliwell B, Gutteridge JMC (2007) Free radicals in biology and medicine, 3rd edn

Table 6 Alterations in gut microbiota and associated functions in MS patients

This astrocyte-neuron lactate shuttle is crucial for maintaining neuronal energy homeostasis when mitochondrial function is impaired (Suzuki et al., 2011