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OCR was measured after serial injections of 3 M Oligomycin (75351, Sigma Aldrich), 2 M phenylhydrazone (FCCP, 1528-10, Sanbio), and 0.5 M Antimycin A (A8674, Sigma Aldrich)

Interestingly, STZ-injected Nrf2 / mice also exhibit more severe cognitive deficits due to hippocampal oxidative damage, an effect associated with chronic hypoglycemia (93)