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Pharmacological inhibition of USP30 activates tissue-specific mitophagy

In neurons, cardiolipin is especially enriched in long-chain PUFAs, particularly docosahexaenoic acid (DHA), which has five bis-allylic carbon atoms

The compound appears to work by increasing intracellular NAD+ levels (through preventing nicotinamide consumption by NNMT), which activates sirtuins and enhances mitochondrial function and fatty acid oxidation, while also promoting a phenomenon called "browning" of white adipose tissue - the transformation of energy-storing white fat cells into metabolically active beige/brown adipocytes that burn fatty acids for thermogenesis rather than storing them

2015) and contributes to glioma progression via several pathways, such as the cell cycle pathway (Yao et al

Patients with severe influenza A virus infection (H1N1, H5N1, and H7N9) were found to have high levels of circulating pro-inflammatory cytokines [58]

Lucht, A