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Signal Transduction Pathways: Receptor binding initiates signal transduction pathways within the somatotroph cells

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J., Ma, Q

The target genes encompass those that encode proteins related to angiogenesis (e.g., Vascular Endothelial Growth Factor (VEGF)), glycolysis (e.g., GLUTs, glycolytic enzymes), tumor survival (e.g., Bcl-2), metastasis, and other factors facilitating adaptation to hypoxia [26]