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This process is subject to reversal by reducing agents, indicating the involvement of cysteine residue(s) as the target for S-nitrosylation (McVey et al., 1999

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During intestinal microbial dysbiosis, the imbalance in the composition of the bile acid pool disrupts the homeostatic regulation of the gut-kidney-bone axis, serving as an important mediating mechanism for the comorbidity of diseases such as CKD, osteoporosis (OP) and osteoarthritis

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