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Abbreviations GSH glutathione SH sulfhydryl group O 2 superoxide H 2 O 2 hydrogen peroxide NOX NADPH oxidase SOD superoxide dismutase HOCl hypochlorous acid HOBr hypobromous acid Fe 2+ ferrous iron OH hydroxyl radical Fe 3+ ferric iron L lipid radical LOO hydroperoxide radical LOOH lipid peroxide HNE 4-hydroxy-2-nonenal ONOO peroxynitrite NO nitrogen oxide nitrite nitrate ONOOH peroxynitrous acid NO 2 nitrogen dioxide CFTR cystic fibrosis transport receptor GPx glutathione peroxidase PHGPx GPx IV phospholipid hydroperoxide glutathione peroxidase GSSG glutathione disulfide Prdx peroxiredoxin PSSG protein mixed disulfide PDI protein disulfide isomerase S thiolate PSOH sulfenic acid GST glutathione-S transferase GSNO nitrosoglutathione DTNB dithionitrobenzoic acid NEM N-ethylmaleimide NaBH 4 sodium borohydride OPT orthophthaldehyde GCL glutamate cysteine ligase ARE antioxidant response element JNK Jun N-terminal kinase GGT -glutamyl transpeptidase

[7] Glutathione vs Collagen: Key Differences How Collagen and Glutathione Work for Different Skin Concerns

Fermented extracts exhibited increased DPPH and ABTS radical-scavenging capacities and significantly reduced nitric oxide production from day six of fermentation

With consistent use, it promotes a more radiant complexion and can gradually contribute to skin whitening

Scientific Overview: Dihexa is a synthetic hexapeptide analogue known for its high affinity to hepatocyte growth factor (HGF) receptors, extensively studied in molecular biology research for its capacity to modulate neurotrophic signalling pathways

Both were published in the New England Journal of Medicine in mid-2025