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We utilised a small molecule approach to differentiate the 4 hPSCs to HLCs as previously described by Siller and colleagues (2015) 11

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Glutamate synthesis and degradation in differently located astrocytes was envisaged to present a possible problem in the suggested interacting pathways of glutamate production and oxidation with its exclusive use of aspartate aminotransferase (Figure 3B) rather than GDH (Hertz, 2) may suggest a back-up function of the GDH

Klein Goldewijk, K., Beusen, A

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