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[DOI] [PubMed] [Google Scholar] 158.Terefe N.S., Buckow R., Versteeg C

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For a comprehensive deep-dive into Ipamorelin's regulatory history, clinical trial status, and comparison with approved alternatives, see our dedicated guide: Ipamorelin FDA Approval Status 2026

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Furthermore, studies have shown that optimizing the structure of the gut microbiota, enhancing the abundance of beneficial bacteria such as Muribaculaceae , reducing the number of MMs in colonic tissue, downregulating pro-inflammatory factor expression, and upregulating BMP2 secretion by MMs can enhance gastrointestinal motility, inhibit neuronal loss, and improve slow transit constipation in mice (Ren et al., 2022)