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The study was designed this way because L-DOPA, though effective in treating Parkinson's symptoms, as stated earlier in the protocol is also known to damage dopamine producing cells and induce dyskinesias

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Skeletal muscle area was measured on the axial image at the level of the third lumbar vertebra (L3)

Abnormal DNMT activity is the main driving factor, for example, DNMT3B overexpression directly induces high methylation of promoters and inhibits tumor suppressor genes [15]

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PMID: 16984983