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Speech can be either high-pitched (Minnie Mouse-esque), or low pitched and hoarse, there may be occasional diplophonia (two vocal tones), and patients may activate accessory facial, tongue and chest wall movements in the struggling production of effortful speech (107)

However, the low degree of inhibition demonstrated by the extract suggested that this type of pathway was not primarily involved in the vasodilation process

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Furthermore, BBR can inhibit colon cancer cell growth by activating retinoid X receptor (RXR), which binds RXR, and promoting -catenin degradation (Ruan et al., 2017)