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Clinically, the treatment strategies during phase I utilize conventional methods: patients should be treated with hypothermia, free radical scavengers (e.g., melatonin, erythropoietin, coenzyme Q10), excitatory amino acid receptor blocking agents, and/or neuroprotective agents

In contrast, based on experimental findings, natural bioactive compounds typically demonstrate a favorable safety profile

The precursor protein of non-A beta component of Alzheimers disease amyloid is a presynaptic protein of the central nervous system

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doi: 10.1038/s41575-019-0186-y 40 HuangJYanLChengZWuHDuLWangJet al

Mohamed MAE, Abdel-Rahman RF, Mahmoud SS, Khattab MM, Safar MM