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We report that Gsta4 restricts apoptosis of pre-myelinating OLs via modulation of the mitochondria-associated Fas-Casp8-Bid-axis, thus enhancing the proportion of OPCs that become myelinating OLs

The Asn33Glu mutation entirely inhibits hydrolysis of 8-oxo-dGTP, while the Asn33Ala mutation retains only 14% activity ( DNA molecules are highly susceptible to reactive oxygen species (ROS)

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M., Marquardt K., Lash L

Research published in Biochemical Pharmacology demonstrates GHK-Cu activating integrin signaling, upregulating nerve growth factor (NGF), and engaging decorin pathways that organize newly synthesized collagen into functional extracellular matrix architecture

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