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Understanding the blend starts with understanding that its two components are pharmacologically unrelated except for a shared downstream output GH release from the anterior pituitary

Berkes S, Liddell K, Beyer K, Blumchen K, Deschildre A, Kukkonen K et al (2025) Re-evaluating treatment success in trials of peanut oral-immunotherapy: impact of different definitions on efficacy outcomes

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Statements Author contributions HY: Writing review & editing, Writing original draft

doi: 10.1080/21691401.2020.1730390 10 AlahmadA.Al-ZereiniW

In the body, the overwhelming majority of circulating IGF-1 is not free it is bound to a family of six IGFBPs that regulate its availability, transport, and clearance, and that generally restrain its biological activity