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: Sikiric, Predrag, et al

The GHR belongs to the class 1 cytokine receptors which uses STAT as one of its principal secondary messengers, and the subsequent phosphorylation of two STAT5b molecules results in a phospo-STAT5b homodimer which translocate to the cell nucleus, binds to STAT5b recognition sites on the IGF1 gene promoter, and initiates transcription (Figure 3)

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[DOI] [PubMed] [Google Scholar] 34.Zhang D, Jia H, Wang Y, Li WM, Hou YC, Yin SW, Wang TD, He SX, Lu SY

Another advantage of GLP-1 injections is their ability to suppress appetite and promote weight loss, an aspect that is beneficial for our patients who also struggle with obesity or prediabetes