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However, AARS is an exception, which relies on lactate-AMP as an intermediate to directly transfer lactyl group to the lysine residues of target proteins with the assistance of ATP [25, 26] As the most well-studied writer, p300-catalyzed lactylation mainly promotes gene transcription [28,29,30,31,32,33,34,35,36,37,38,39] and maintains normal protein structure and functions [40,41,42,43,44,45]

Studies of enzyme kinetics revealed that the Michaelis constant (Km) values of PHDs for O 2 are higher than those of CPHs, which results in the capacity of PHDs to sense changes in cellular oxygen levels [38]

For the first yield assessment, the elemental sulfur was applied at concentrations of 0, 0.2, 0.4, and 0.8 mg/L, while for the second yield assessment, it was applied at concentrations of 0, 0.4, 0.8, and 1.6 mg/L, with 50 mL per pot for each treatment

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