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10.1038/cdd.2014.139 Cell Death Differ

Depletion of beneficial taxa such as Odoribacter (Bacteroidetes) and Lachno Clostridium (Firmicutes), along with increased abundance of pro-inflammatory taxa including Ileibacterium and Olsenella , was associated with reduced SCFA gene expression, downregulation of tight junction proteins (occludin and claudin-1), and microglial activation in the amygdala and arcuate nucleus, indicating gut barrier disruption and neuroinflammation that coincided with anxiety-like behavior

It occurs, however, when you damage the ligament through repeated stress on the ulnar collateral ligament of the thumb

Kobayashi, Y., Fukami, T., Shimizu, M., Nakajima, M

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