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doi: 10.1038/s41416-018-0155-1 96 AndrewsMCDuongCPMGopalakrishnanVIebbaVChenWSDerosaLet al

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Elevated TPO antibodies indicate: Autoimmune attack against the thyroid Ongoing inflammation Gradual destruction of thyroid tissue In early stages, thyroid levels may fluctuate as antibodies intermittently damage thyroid cells