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So the first honest distinction is structural: tesamorelin is a modified full-length analog engineered for resistance to degradation, whereas sermorelin is an unmodified short fragment that reproduces GHRH activity but not GHRH stability

It is recognised as one of the first growth hormone-releasing peptide receptor agonists designed with high selectivity for growth hormone stimulation

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Reviewer #1 The present manuscript describes the role of the GHSR in intracellular signaling on its own and in a variety of molecular interactions with other receptors as well as the potential for stimulation of GHSRs as a therapeutic target for a wide-range of clinical conditions