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Although the methodology for calculating Tg-DT/Tg-DR is rather complicated, calculation software can be downloaded from the homepage of Kuma Hospital, making the calculation easy simply by assigning values ( 2) Tumor volume doubling time (TV-DT) and tumor volume doubling rate (TV-DR) This is a concept established under the hypothesis that the speed of growth of metastatic/recurrent tumors affects patient prognosis

Kolev, M

W., Perrar, I., Penczynski, K

Integrating such data into clinical translation will facilitate the rational design of dosing schedules that balance efficacy with safety

cGAS conformational changes limit its enzymatic activity, which inhibits cGAS DNA binding and dimerization, although cGAS palmitoylation does not affect its subcellular localization (68)