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The nature of the cholinergic hypothesis is based on the suppressed synthesis of the neurotransmitter acetylcholine and therefore the therapeutic intervention is based on the restoration of the physiological level of acetylcholine by inhibiting the activity of enzyme acetylcholinesterase (AChE) (Bartus et al

Jan-Feb 2020;38 Suppl123(1):99-104

NSAIDs can cause sodium and fluid retention as well as increase peripheral vascular resistance

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J Lab Clin Med 70:158169 Adams JD, Lauterburg BH, Mitchell JR (1983) Plasma glutathione and glutathione disulfide in the rat: regulation and response to oxidative stress

However, with VIM DBS, effective tremor suppression can sometimes come with the price of worsening gait ataxia, a clinical observation that suggests that different neuronal coding mechanisms for tremor and ataxia lie within the same cerebello-thalamo-cortical loop [189]