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In the last few years, various GSH modulation-enhanced combinational therapy strategies have been extensively exploited, accompanied by the development of versatile metal-based nanosystems with different structures, functionalities, and treatment performances ( In view of the rapid development of GSH-responsive and -exhausting metal nanomedicines in potentiating cancer therapy, we summarize and outline the recent advancements, mechanisms, prospects, and challenges in this field from different strategies (Scheme 1)

Antioxidants (vitamin C, glutathione) to handle the oxidative stress from prolonged exertion

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Accordingly, less susceptibility of alcohol and isoniazid was observed in CYP2E1-knockout mice in an ALI setting (Lee et al., 1996)

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In unstressed plants ONOO was continuously scavenged by PrxIIE, which was inhibited by S-nitrosylation in course of the HR (Romero-Puertas et al., 2007)