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Further demonstrating the therapeutic potential of targeting glycolysis, the natural compound derivative D5, sourced from Radix Aucklandiae, attenuates colitis in mice by impeding the nuclear translocation of PKM2 dimers, thereby suppressing glycolytic flux and Th17 cell differentiation (211)

Andrea Maier, a professor of medicine at the National University of Singapore who runs the Chi Longevity Clinic at the Four Seasons there, said that the clinical evidence simply isn't there yet for a lot of these peptides

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Additionally, the production of glucose-derived TCA cycle metabolites, such as citrate, KG, and succinate, was decreased (Supplementary Fig

All figures in this study were generated using BioRender Dambrine, F

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