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P-gp upregulation may be blocked by natural curcuminoids, a novel class of chemoresistance-preventing agent

Additionally, studies in animal models reveal that topically applying a lotion with PLA2G4B-siRNA can deactivate immature CD8+ T cells at cutaneous lesion sites in IMQ mice, thus mitigating the secretion of pro-inflammatory molecules like IL-17 and IL-36 (97)