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These compounds are known to play a role in glutathione production, which helps combat oxidative stress and supports metabolic processes [1][2]

Moreover, gut microbiota-derived metabolites, including D-amino acids and reactive oxygen species, contribute directly to glomerular and tubular dysfunction by promoting oxidative stress and insulin resistance (Nagase et al., 2022)

The evidence presented above notwithstanding, the 2020 guidelines for the prevention of CIPN issued by the American Society of Clinical Oncology do not yet endorse GM1 for prevention or treatment of CIPN, citing insufficient evidence (Loprinzi, Lacchetti 2020)

To dig deeper into that idea, our All About Liposomes page is a helpful place to start

Yevenes-Briones H, Caballero FF, Struijk EA, Lana A, Rodriguez-Artalejo F, Lopez-Garcia E