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Upon activation of a G protein-coupled receptor, the rise of free cytosolic Ca 2+ concentrations is preceded by the hydrolysis ofphosphatidylinositol4,5-bisphosphate

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1,3 Disulfides are thermodynamically stable at physiological pH and are designed to release the conjugated payload drug upon internalization into the tumor cells, where the cytosol provides a much stronger reducing environment compared to the extracellular environment (blood circulation)

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