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Meperidine (initial dose 2550 mg i.v.) has shorter half-life but puts patients are at higher risk of metabolite accumulation (neuromuscular side effects) when repeated doses accumulate

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Initial low-dose gentamicin for Staphylococcus aureus bacteremia and endocarditis is nephrotoxic

These results revealed previously unknown metabolic phenotypes, identified new developmental states of the metabolic correlation network, and underscored the role of mitochondrial functional changes, purine metabolism, and purinergic signaling in autism spectrum disorder

Together, oxidative stress and excitotoxicity form a dual mechanism that underpins the neural damage caused by N 2 O exposure