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For B12 supplementation experiments, we used the previously mentioned B12-deficient diet (Diet #1 in the text

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Vitamin B 12 deficiency was more common in metformin-exposed individuals, with an incidence of 6.02% in the GG genotype group, 7.96% in the AG genotype group and 12.84% in the AA genotype group

Research models have examined whether these effects contribute to improved nutrient delivery and cellular responses during tissue stress