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Moreover, an enriched subgroup analysis of the URICOI-ICTUS trial revealed that UA treatment was safe, well-tolerated, and provided substantial benefits of UA in terms of the primary outcome(modified Rankin Scale score at day 90)

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Rushmore, T

This is confirmed by immunoprecipitations and Western blot analysis in this study

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The 200, 100 and 50 ng/mL of PC spikes signaled above the cut point in the presence of 50 ug/mL of PC, indicating drug tolerance well above the C max value reported for the highest dose of pegadricase administered in the clinical study (Supplementary Fig