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Vascular Function Improvement Evidence: Animal + In Vitro | Quality: Emerging A 2025 study demonstrated that FOXO4-DRI regulates endothelial cell senescence via the p53 signaling pathway and improves vascular function in aged mice

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A: Main disadvantages include: high cost for long-term use, results arent permanent (maintenance required), potential for uneven whitening without sun protection, rare side effects (nausea, headache), and dependency on clinic visits

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Diet folate, DNA methylation and polymorphisms in methylenetetrahydrofolate reductase in association with the susceptibility to gastric cancer