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The hypoxic environment will activate protective autophagy in EGFRVIII-GBM, luckily patients can get benefit from synergistic treatment with chloroquine (CQ) [151], which blocks autophagy by inhibiting autophagosome-lysosome fusion and subsequent lysosome degradation [152]

Rosuvastatin inhibits spontaneous and IL-1-induced interleukin-6 production from human cultured osteoblastic cells

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