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4.1 Binge drinking model The acute alcohol intragastric model can simulate the liver damage caused by binge ethanol in people with no drinking history

The construction completion is anticipated in the summer of 2025

All RT-qPCR primers can be searched in support information (Table S1)

Macrophages are primarily derived from bone marrow-resident haematopoietic stem cells (112)

Glutathione synthetase in erythrocytes and/or cultured fibroblasts can be measured as described elsewhere [1]

NIOD's third-generation Copper Amino Isolate Serum 3 1:1 (CAIS) plays a comprehensive role in skin aging and helping maintain the look of healthy skin as the skin ages over time