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Severe metabolic acidosis (pH 7.12, bicarbonate 6 mmol/L and p CO 2 3.2 kPa) suggested poor tissue perfusion presumed to be the result of sepsis and the baby was admitted to intensive care

We hypothesized that oxidation of GSH to glutathione disulfide (GSSG) in the epithelial lining fluid (ELF) of children with severe asthma would contribute to altered airway macrophage (AM) GSH homeostasis and AM cellular dysfunction

The disorder is diagnosed by genetic testing or by blood tests that measure methionine or homocysteine levels

Novel small molecules targeting FSP1 are currently under investigation to induce ferroptosis in GBM cells

L.GrigoriuS.KimY.ArrudaJ

-- Functional divergence of SIR2 orthologs between trypanosomatid parasites