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doi: 10.1007/s00125-018-4611-5 143 RussellD

Further, the study may not have adequately considered differences in response to microneedle patches in different individuals (e.g., based on age, sex, and health status)

Coinhibitory pathways such as PD-1, CTLA-4 and Tim-3 have been proved to be upregulated in chronic viral hepatitis and critical in hepatic tolerance, contributing to the failure of T-cell response to hepatic pathogens such as HBV, which can be regarded as novel indicators of T-cell immune function in patients with chronic HBV infection

The most critical class of ligands for innate immune receptors consists of nucleic acids: exogenous DNA, RNA released during viral infection, and double-stranded RNA (dsRNA), which serves as an intermediate in viral RNA-dependent replication [211]

In addition, zonal differences in hepatic insulin signaling, non-classical insulin signaling pathways, and activation of the mechanistic target of rapamycin complex 1 and protein kinase C pathways appear to be involved in the development of selective hepatic IR

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