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Additionally, the qPCR data revealed that A2ARi significantly increased gene expression of gpx4 and gclc , and the addition of Lip-1 further resulted in increased expression of these GSH-related genes in the presence of A2ARi (Supplemental Figure 8, A and B)

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These activators have shown neuroprotective efficacy in animal models of chemotherapy-induced peripheral neuropathy (CIPN)

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