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Abstract The cause of insulin resistance in obesity and type 2 diabetes mellitus (T2DM) is not limited to impaired insulin signalling but also involves the complex interplay of multiple metabolic pathways

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These observations in RNA-seq data were further validated by qRT-PCR for selected Wnt/-catenin pathway-related genes including AMER3 , NRARP , CCND1 , LRG1 , and LEF1 in hDP cells exposed with various doses of NTAPP (3.6 kV, 4.2 kV, and 5.0 kV) (Fig

( D ) Verification of the cell cycle progression