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In conclusion, prolonged exposure to the optimum fluoride level of artificially fluoridated water was not associated with cognitive impairments, while a higher concentration associated with fluorosis triggered memory and learning deficits, associated with a neuronal density reduction in the hippocampus

Gene-expression profiling studies have reported that GHK-Cu alters the transcription of a broad set of genes linked to tissue remodeling, antioxidant defense, and inflammatory signaling

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Oxidative stress plays a role in downregulation of the transcription factor MAFA, which influences insulin secretion by pancreatic beta cells [82]