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Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is another versatile bioactive protein involved in various tissue repair processes such as wound healing, periodontal regeneration, and neurogenesis following ischemic injury by functioning on numerous cell types [170]

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Its also thought to form new blood vessels, reduce inflammatory markers, and promote stem cell differentiation

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64 68 For this reason, the section below titled Diagnosis is based on Clinical Principles or Expert Opinion with consensus achieved using a modified Delphi technique when differences of opinion emerged

Meka, H., Werner, F., Cordell, S