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This was compared to a 3.1% weight loss in those taking a placebo

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10.1007/s10787-017-0323-6 76 MihovilI.RadicB.BrcicL.BrcicI.VukojaI.IlicS.et al (2009)

Trial subjects reported improved skin hydration within 1-2 weeks, noticeable texture and firmness improvements at 4-8 weeks, and reduced fine lines with better skin resilience at 8-12+ weeks

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Always use a new, sterile needle for each injection and dispose of used needles properly in a designated sharps container