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Rapidly proliferating cells often upregulate PHGDH to meet the demand for serine and related metabolites [145]

alters the secondary structure of the enzyme, which subsequently leads to a change in the tertiary and quaternary structures [105], affecting the ability of the GSTP1-1 to interact with proteins

Moreover, where lifespan effects were not seen, this may in some instances be due to the use of too low a concentration

10.1046/j.1471-4159.1999.0731127.x [DOI] [PubMed] [Google Scholar] Betarbet R, Sherer TB, MacKenzie G, Garcia-Osuna M, Panov AV, Greenamyre JT, 2000

In mouse models of diseases such as ALI, liver fibrosis, NAFLD, and NASH, treatment with lipophilic antioxidants was shown to prevent disease progression and extend life expectancy

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